If the Americans do not withdraw from positions they now hold in Syria, or if the United States conducts more punitive airstrikes against the Damascus regime, Assad predicted there would be "direct conflict between the Russian forces and the American forces".
"This is the first option".
The province had been the subject of a race between the Russian-backed Assad government forces and the SDF, each trying to outpace its rival.
"The Americans should leave somehow".
"They looked for another card". They have to learn their lesson. Iraq is no exception, and Syria is no exception. "People will not accept foreigners in this region anymore", Assad said.
Elsewhere, Assad was asked about the possibility of an assault by the U.S. and its allies on Syria similar to the tripartite missile attack last month.
The U.S. -backed group holds the largest area of Syrian territory outside government control, but has tried to avoid direct clashes with the government during the multi-sided war.
It was not the first time that Assad has threatened to attack US troops, but it was his most explicit expression yet of his determination to rid Syria of American forces.
Turkey also says the USA should drop its support to the SDF, which is mainly established by the People's Protection Units (YPG), the Syrian arm of the outlawed Kurdistan Workers' Party (PKK), according to Ankara.
In northern Syria, Turkish and United States officials last week agreed on a "roadmap" for further cooperation to ensure the security of a Kurdish-held city which became a major headache between the North Atlantic Treaty Organisation allies, according to a joint statement.
"This is not my language, so, I can not use similar language".
According to him, Israel and Russian Federation have been intensively discussing the issue of Iran's military presence in Syria, which "is aimed against Israel".
He added: "I think there is a very known principle, that what you say is what you are".
In his interview with RT, Assad also accused Israel of lying about Iranian troops on the ground in Syria.
Assad also sought in his interview to minimize the extent to which his government receives support from Iran.
Assad further said Israel has from the start of the crisis in Syria been in contact with the anti-Damascus militants.
If Bashar Assad is winning the hearts of the surviving Syrians, he did it by stopping a horrific amount of hearts and driving 13 million people out of their homes, half of them leaving the country entirely.
"We don't have any other option". The terrorists, he said, took aim at Syria's air defenses as their primary target, something that reveals they are serving Israeli interests.