They are generally caused by pregnancy or blood vessels weakening with age.
PAD: 10.73 for the varicose veins group vs 6.22 for the control group per 1000 person-years (16,615 versus 9709 cases); ARD 4.51 (95% CI). However, the association to these conditions was "less clear due to the potential for confounding", by factors such as smoking history or obesity - information not available in the claims data.
The China Medical University group are uncertain whether the varicose veins really cause blood clots, or whether they are a side effect of more profound issues which are a typical reason for both varicose veins and the more genuine clotting issues.
"We believe that varicose veins are not merely a cosmetic or symptomatic concern", Chang concluded.
Varicose vein patients, then, "had about a 5 times greater risk of developing deep vein thrombosis than the other group", said Chang. Overall, the HR for the patients with varicose veins with PAD was 1.72 (95% CI 1.68-1.77) compared with the control group. "Due to the strong relationship between varicose veins and the increased risk of more serious disease, patients with varicose veins deserve careful monitoring and early evaluation".
Every year around 25,000 people in the United Kingdom bite the dust from a blood clot in a vein, and the condition is additionally the third driving reason for heart assaults and strokes.
Important to the study design was the fact that the three endpoints were analyzed separately, i.e., if a patient with DVT later developed PE or PAD, these were counted as cases in the analysis of the other endpoint (s). Moreover, patients with chronic venous diseases have increased leukocyte adhesion and more activated leukocytes. Benefits associated with varicose vein treatment providing effectiveness of cost and time, low risk of postoperative complications and, painless procedure is expected to augment the growth of global varicose vein treatment over the forecast period.
Dr. Andrei L. Kindzelski, program director at the Translational Blood Science and Resources Branch at the National Heart, Lung and Blood Institute, also said the findings "are not new or unexpected". The major weakness is that the study is not a "true" population study. Researchers tracked more than 200,000 patients and say more study is needed. Have you ever experienced a blood clot or deep-vein thrombosis?