Drummond will take his place on LeBron James' team for the match at the Staples Centre in Los Angeles.
Washington point guard Wall has been bothered by a left knee injury and will undergo surgery that is expected to sideline him for close to two months.
The league announced today that commissioner Adam Silver has selected Drummond as the replacement.
Wall is just one of now three All-Stars who will have to miss the game due to injury.
Silver instead chose a frontcourt player, picking Pistons center Andre Drummond to replace Wall in the All-Star Game.
In the end, he went with a player who has improved by leaps and bounds over last season, especially on the offensive side of the floor. The six-year National Basketball Association veteran has 176 assists this season, 19 more than in his previous two campaigns combined.
Amond those players is Simmons of the 76ers who is putting up 16.6 points, 7.3 assists and 7.9 rebounds per game in his rookie season. "No (t) sure why Jaylen Brown is confused", said Drummond in the comments. There was some hope in Boston that Jaylen Brown would find his way onto the roster, and the second-year guard even received an endorsement from Warriors All-Star Draymond Green.
Drummond is having a fine season for a Pistons team that is now poised to make a run to the playoffs after acquiring Blake Griffin in a trade yesterday from the L.A. Clippers. Additionally, Drummond's making 54.9 percent of his shots and 61.9 percent of his free throws, another drastic improvement.